A driving method of a display panel and a display device are provided, wherein the driving method of the display panel can make a sub-pixel to be driven disposed in a splicing region display normally by compensating the sub-pixel to be driven disposed in the splicing region. A dark line appearing in the splicing region is eliminated, and a technical problem of splicing dark line appearing in the splicing region of a display device adopting spliced mini-LEDs is alleviated.