A cooler with a secondary compartment. The cooler with a secondary compartment has a base and at least one sidewall disposed around a perimeter of the base thereby defining an interior volume. A lid can be removably secured to an open end of the sidewall. A selectively removable tub can be dimensioned to fit within the interior volume. In one embodiment, at least one interior shelf is disposed in the interior volume thereby forming a first compartment and a secondary compartment, such that the first compartment is in thermal communication with the secondary compartment. In one embodiment, at least one door can be disposed on the sidewall wherein the door provides access to the interior volume. In another embodiment at least one drawer, dimensioned to fit within the interior volume, can be slidably removable.