US Patent 11208429 Modified nucleic acid monomer compound and oligonucleic acid analog

Patent 11208429 was granted and assigned to Eisai on December, 2021 by the United States Patent and Trademark Office.

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Patent Citations Received

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US Patent 12006499 Una amidites and uses thereof

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Patent abstract

The present invention provides a modified nucleic acid monomer compound having a specific backbone such as 2-ethylglycerol or methoxymethyl-1,3-propanediol backbone instead of a ribose or deoxyribose backbone of a nucleoside, and an oligonucleic acid analogue containing the monomer compound as at least one of building blocks. The oligonucleic acid analogue containing the nucleic acid monomer compound of the present invention allows provision of an oligonucleic acid analogue having excellent biological stability and/or target gene silencing activity.

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Patent Inventor Names

Yoshinori Takahashi0

Yuta Suzuki0

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