Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Luhan Yang0
Margo R. Monroe0
George M. Church0
Date of Patent
December 28, 2021
0Patent Application Number
160752470
Date Filed
February 2, 2017
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Methods and compositions of altering mitochondrial DNA of a eukaryotic cell are provided using one or more of a mitochondrial specific adeno-associated virus to deliver one or more nucleic acids encoding CRISPR system including a Cas9 protein or its nuclease inactive variant and a guide RNA into a mitochondria for expression within the mitochondria. The Cas9 system can cut, nick or regulate a target mitochondrial nucleic acid.
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