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US Patent 11242524 HTP genomic engineering platform for improving fungal strains

Patent 11242524 was granted and assigned to Zymergen on February, 2022 by the United States Patent and Trademark Office.

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Patent Applicant

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Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Paolo Boccazzi0

Patrick Westfall0

Sara da Luz Areosa Cleto0

Sean Poust0

Vytas SunSpiral0

Kenneth S. Bruno0

Jennifer Fredlund0

Kyle Rothschild-Mancinelli0

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Date of Patent

February 8, 2022

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Patent Application Number

172073760

Date Filed

March 19, 2021

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Patent Citations

US Patent 10058865 Actuated microfluidic structures for directed flow in a microfluidic device and methods of use thereof

US Patent 10239058 Methods, systems and devices for selection and generation of genome edited clones

US Patent 10245588 Providing DEP manipulation devices and controllable electrowetting devices in the same microfluidic apparatus

US Patent 10252907 Exporting a selected group of micro-objects from a micro-fluidic device

US Patent 10336998 Microbial strain improvement by a HTP genomic engineering platform

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US Patent 10350594 Lateral/vertical transistor structures and process of making and using same

US Patent 10384204 Systems for operating electrokinetic devices

US Patent 10407658 Well plate incubator

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Patent Citations Received

US Patent 11479779 Systems and methods for high-throughput automated strain generation for non-sporulating fungi

Patent Primary Examiner

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Patent abstract

A HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols is provided. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. Methods for isolating clonal populations derived from individual fungal spores are also provided.

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