Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Thomas P. Bobinski0
Anthony Joseph Varano, Jr.0
Matthew Randolph Lee0
Date of Patent
February 15, 2022
Patent Application Number
16867162
Date Filed
May 5, 2020
Patent Citations
Patent Primary Examiner
Patent abstract
The present invention relates to indoline-based compounds that inhibit Rho-associated protein kinase (ROCK) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.
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