Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jeffrey A. Hubbell0
David Scott Wilson0
Kristen Marie Lorentz0
Stephan Kontos0
Date of Patent
February 22, 2022
0Patent Application Number
166227320
Date Filed
June 14, 2018
0Patent Citations
Patent Citations Received
Patent Primary Examiner
Patent abstract
Several embodiments provided in the present disclosure relate to compositions that carry an antigen to which tolerance is desired, the antigen being coupled, bound, or otherwise joined to a targeting moiety, the targeting moiety configured to direct the composition to the liver of a subject. In several embodiments, the antigen in coupled to the targeting moiety by way of a polymeric linker. In several embodiments, the polymeric linker is configured to liberate the antigen in vivo. Methods of using the compositions to reduce and/or prevent unwanted immune responses against an antigen of interest are also provided.
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