Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
March 1, 2022
Patent Application Number
16487762
Date Filed
February 20, 2018
Patent Citations
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention aims to provide an antisense oligonucleic acid with reduced hepatotoxicity. The antisense oligonucleic acid according to the present invention is characterized in that it has a base length of not less than 7 nt and not more than 30 nt, wherein nucleic acid residues of not less than 1 nt and not more than 5 nt respectively from the both terminals are 2′,4′-bridged nucleic acids, 2′,4′-non-bridged nucleic acid residue(s) is(are) present between the above-mentioned both terminals, and one or more bases in the nucleic acid residue(s) of the above-mentioned 2′,4′-non-bridged nucleic acid residue(s) is/are modified.
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