Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
March 15, 2022
Patent Application Number
16624335
Date Filed
June 21, 2018
Patent Citations Received
Patent Primary Examiner
CPC Code
Patent abstract
Herein is described the conversion of deoxynybomycin (DNM), a natural product and DNA gyrase inhibitor with minimal cytotoxicity, into a compound (Formula I) that has anticancer activity. Detailed in vitro and cell culture experiments demonstrate that these compounds inhibit Top2 and also act upon topoisomerase I. Similar approaches are applicable to other classes of gyrase inhibitors and other antibacterial targets for discovery of new anticancer drugs.
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