A wheel brush for a wheelchair has an inverted U-shaped brush housing that has a longitudinal channel and an open bottom. A brush head is slidably received within the channel such that bristles located on the brush head extend out through the open bottom of the brush housing. The open bottom is sufficiently narrow as to prevent the brush head from passing therepast. A resilient clip is attached to the brush housing and is clipped to a vertical post of the wheelchair, such as the arm rest post, and is positioned so that the bristles engage a portion of the outer periphery of one of the wheels so as to brush clean the wheels whenever the wheelchair rolls and the rear wheels rotate.