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US Patent 11286468 Engineered CRISPR-Cas9 nucleases with altered PAM specificity

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

J. Keith Joung0

Benjamin Kleinstiver0

Date of Patent

March 29, 2022

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Patent Application Number

161096570

Date Filed

August 22, 2018

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Patent Citations

US Patent 10633642 Engineered CRISPR-Cas9 nucleases

US Patent 10501794 Genomewide unbiased identification of DSBs evaluated by sequencing (GUIDE-seq)

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US Patent 10526591 Engineered CRISPR-Cas9 nucleases

US Patent 10093910 Engineered CRISPR-Cas9 nucleases

US Patent 10266850 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

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Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.

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