A system for patient positioning is provided. The system may acquire image data relating to a patient holding a posture and a plurality of patient models. Each patient model may represent a reference patient holding a reference posture, and include at least one reference interest point of the referent patient and a reference representation of the reference posture. The system may also identify at least one interest point of the patient from the image data using an interest point detection model. The system may further determine a representation of the posture of the patient based on a comparison between the at least one interest point of the patient and the at least one reference interest point in each of the plurality of patient models.