A footwear cleaning system including an outer housing that encases an internal compartment, which is designed, sized, and shaped to receive a footwear item therein, such as an athletic shoe, dress shoe, platform shoe, or other similar footwear item. The footwear cleaning system includes one or more rotatable cleaning disks disposed within the internal compartment, such that the cleaning disks are configured to interact with a bottom surface of a footwear item. One or more fluidic conduits terminate at a location that is proximate to the internal compartment, such that water, cleaning solutions, concentrated cleaning products, alcohol, and other fluids can be dispelled into the internal compartment to interact with a footwear item.