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US Patent 11299491 Synthesis of key intermediate of KRAS G12C inhibitor compound

Patent 11299491 was granted and assigned to Amgen on April, 2022 by the United States Patent and Trademark Office.

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Is a

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Patent attributes

Patent Applicant

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Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Andrew Thomas Parsons0

William Powazinik, IV0

Marc Anthony Caporini0

Brian McNeil Cochran0

Date of Patent

April 12, 2022

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Patent Application Number

166858410

Date Filed

November 15, 2019

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Patent Citations

US Patent 10519146 KRAS G12C inhibitors and methods of using the same

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US Patent 10532042 KRAS G12C inhibitors and methods of using the same

US Patent 10640504 Inhibitors of KRAS G12C and methods of using the same

US Patent 10988485 KRAS G12C inhibitors and methods of using the same

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US Patent 11045484 KRAS G12C inhibitors and methods of using the same

US Patent 11053226 KRAS G12C inhibitors and methods of using the same

US Patent 11090304 KRAS G12C inhibitors and methods of using the same

US Patent 11096939 KRAS G12C inhibitors and methods of using the same

Patent Citations Received

US Patent 12083121 Substituted piperazines as KRAS G12C inhibitors

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US Patent 11993597 Inhibitors of KRAS G12C and methods of using the same

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US Patent 11918584 Combination therapy including a KRAS

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US Patent 11905281 KRAS G12C inhibitors and methods of using the same

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US Patent 11766436 KRAS G12C inhibitors and methods of using the same

US Patent 11426404 Dosing of

Patent Primary Examiner

Jeffrey S Lundgren

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CPC Code

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Patent abstract

The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure

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