A method of forming a membrane panel configured to be secured within an energy exchange assembly may include forming an outer frame defining a central opening, and integrating a membrane sheet with the outer frame. The membrane sheet spans across the central opening, and is configured to transfer one or both of sensible energy or latent energy therethrough. The integrating operation may include injection-molding the outer frame to edge portions of the membrane sheet. Alternatively, the integrating operation may include laser-bonding, ultrasonically bonding, heat-sealing, or the like, the membrane sheet to the outer frame.