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US Patent 11304924 Pharmaceutical compositions comprising nitroxyl donors

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

John P. Toscano0

Vincent Jacob Kalish0

Stephen Martin Courtney0

Lisa Marie Frost0

John Reardon0

Frederick Arthur Brookfield0

Date of Patent

April 19, 2022

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Patent Application Number

167790150

Date Filed

January 31, 2020

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Patent Citations

US Patent 10792273 Nitroxyl donors with improved therapeutic index

US Patent 10829445 N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

US Patent 10179765 N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

US Patent 10213408 Nitroxyl donors with improved therapeutic index

US Patent 10245249 Pharmaceutical compositions comprising nitroxyl donors

US Patent 10487049 N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

US Patent 10517847 Nitroxyl donors with improved therapeutic index

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US Patent 10548872 Pharmaceutical compositions comprising nitroxyl donors

Patent Citations Received

US Patent 11786501 Nitroxyl donors with improved therapeutic index

Patent Primary Examiner

Sahar Javanmard

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CPC Code

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The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration.

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