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US Patent 11311578 Restimulation of cryopreserved tumor infiltrating lymphocytes

Patent 11311578 was granted and assigned to Iovance Biotherapeutics, Inc. on April, 2022 by the United States Patent and Trademark Office.

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Patent Applicant

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Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Michael T. Lotze0

Ian Frank0

Date of Patent

April 26, 2022

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Patent Application Number

174809000

Date Filed

September 21, 2021

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Patent Citations

US Patent 10517894 Restimulation of cryopreserved tumor infiltrating lymphocytes

US Patent 10420799 Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

US Patent 10894063 Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

US Patent 11026974 Restimulation of cryopreserved tumor infiltrating lymphocytes

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US Patent 10130659 Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

US Patent 10166257 Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

US Patent 10272113 Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

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Patent Citations Received

US Patent 11618877 Aseptic tissue processing method, kit and device

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US Patent 11618878 Aseptic tissue processing method, kit and device

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US Patent 11767510 Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof

Patent Primary Examiner

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The present disclosure provides methods for re-stimulating TIL populations that lead to improved phenotype and increased metabolic health of the TILs and provides methods of assaying for TIL populations to determine suitability for more efficacious infusion after re-stimulation.

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