Is a
Patent attributes
Patent Applicant
0
Current Assignee
0
Patent Jurisdiction
Patent Number
Patent Inventor Names
Eric Escobar-Cabrera0
Surjit Bhimarao Dixit0
Nina E. Weisser0
Mario Sanches0
Grant Raymond Wickman0
Gordon Yiu Kon Ng0
Date of Patent
May 10, 2022
0Patent Application Number
160110480
Date Filed
June 18, 2018
0Patent Primary Examiner
CPC Code
Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.
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