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US Patent 11337427 Antimicrobial agents and their use in therapy

Patent 11337427 was granted and assigned to Norwegian University of Science and Technology on May, 2022 by the United States Patent and Trademark Office.

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Patent abstract

The present invention provides an agent, or a composition containing an agent, for use in treating or preventing a bacterial infection in a subject, wherein said agent comprises:(i) an oligopeptidic compound comprising a PCNA interacting motif and a domain that facilitates the cellular uptake of said compound,wherein the PCNA interacting motif is X1X2X3X4X5 (SEQ ID NO: 1) andwherein:X1 is a basic amino acid;X2 is an aromatic amino acid;X3 is an uncharged amino acid other than an aromatic amino acid, Glycine (G) and Proline (P);X4 is any amino acid other than Proline (P), an acidic amino acid or an aromatic amino acid; andX5 is a basic amino acid or Proline (P); or(ii) a nucleic acid molecule comprising a sequence encoding the oligopeptidic compound of (i).

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