An animal treatment and handling device and method includes a fabric bag sized and shaped to receive the animal's torso and legs therein, with dorsal and ventral surfaces extending longitudinally from an anterior to a posterior end. The bag includes an adjustable collar at the anterior end, and a first zipper extending along the dorsal surface from an anterior end portion to a posterior end portion. An integral, elongated outer wrap extends transversely with a length sufficient to be wrapped around the bag and the animal therein to impart a uniform, calming pressure to the animal's thorax. A plurality of alternately openable and closable doors provide physician access to the animal through the bag and through the outer wrap.