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US Patent 11345932 Methods and systems for guide RNA design and use

Patent 11345932 was granted and assigned to Synthego on May, 2022 by the United States Patent and Trademark Office.

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Patent Applicant

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Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

David Conant0

Richard Stoner0

Travis Maures0

Date of Patent

May 31, 2022

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Patent Application Number

164188930

Date Filed

May 21, 2019

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Patent Citations

US Patent 10337001 Guide RNA with chemical modifications

US Patent 10337029 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

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US Patent 10351878 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

US Patent 10354746 Methods and systems for identifying CRISPR/Cas off-target sites

US Patent 10358658 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

US Patent 10362771 Method for knock-in of DNA into target region of mammalian genome, and cell

US Patent 10358659 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

US Patent 10000772 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

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Patent Citations Received

US Patent 11802296 Methods and systems for guide RNA design and use

Patent Primary Examiner

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CPC Code

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The present disclosure provides a method for designing a set of guide RNAs for hybridizing a genomic region of interest. The present disclosure further provides methods of editing at least one genomic region of interest with at least one set of guide RNAs.

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