A surgical instrument includes a reusable assembly having an inner tube and an ultrasonic blade positioned within the inner tube. The inner tube includes at least one opening to receive a sterilization fluid therethrough for sterilizing the ultrasonic blade within the inner tube. The surgical instrument further includes a sterilization detection system to determine whether the reusable assembly has been sterilized during a sterilization cycle. A seal is selectively couplable with the at least one opening of the inner tube to fluidly seal the at least one opening for inhibiting bodily fluid from entering the at least one opening during a surgical procedure.