Patent 11352646 was granted and assigned to American Gene Technologies on June, 2022 by the United States Patent and Trademark Office.
Viral vectors, lentiviral particles, and modified cells are disclosed. They encode or express a small RNA capable of targeting the KIF11 gene. In embodiments, the viral vectors and lenti viral particles further comprise and a KIF11 gene whose non-coding region has been modified such that it is resistant to activity by the small RNA.