An antenna structure with wide bandwidth in a reduced physical space includes a housing, a side wall, and a first feed portion. The housing includes a metal side frame, a metal middle frame, and a metal back board. The side wall is made of metal material. The metal middle frame and the metal back board are coupled to two sides of the side wall, and the metal middle frame is parallel to the metal back board. The metal side frame surrounds the metal back board. The metal side frame defines at least one gap. The metal back board defines a slot. The slot and the at least one gap cooperatively divide at least two radiation portions from the metal side frame. A wireless communication device employing the antenna structure is also provided.