A refrigeration system includes: a leak sensor disposed within a building and configured to measure an amount of refrigerant that has leaked from the refrigeration system within the building; an estimation module configured to determine an estimated amount of refrigerant that has leaked from the refrigeration system within the building based on the measured amount; and a leak module configured to: determine whether a leak is present in the refrigeration system within the building based on the estimated amount of refrigerant that has leaked from the refrigeration system; and take one or more remedial actions when a leak is present in the refrigeration system within the building.