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US Patent 11377456 Crystalline form of Remdesivir

Patent 11377456 was granted and assigned to Apotex on July, 2022 by the United States Patent and Trademark Office.

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Is a

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Patent Applicant

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Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Fabio E. S. Souza0

Allan W. Rey0

Alexander J. Stirk0

Date of Patent

July 5, 2022

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Patent Application Number

176014930

Date Filed

May 25, 2021

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Patent Citations

US Patent 10065958 Methods and compounds for treating Paramyxoviridae virus infections

US Patent 10675296 Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections

US Patent 10251904 Methods for treating arenaviridae and coronaviridae virus infections

US Patent 10836787 Crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5- (4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate

Patent Citations Received

US Patent 12012431 Methods of preparing 1′-cyano nucleosides

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US Patent 11851438 1′-cyano nucleoside analogs and methods for treatment of viral infections

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US Patent 11903953 Remdesivir treatment methods

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US Patent 11926645 Compounds and methods for treatment of viral infections

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US Patent 11939347 1′-cyano nucleoside analogs and uses thereof

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US Patent 11975012 Remdesivir treatment methods

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US Patent 11780844 Compounds and methods for treatment of viral infections

Patent Primary Examiner

Traviss C Mcintosh, III

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The present invention provides a novel crystalline form of remdesivir, remdesivir Form APO-I, including remdesivir and dimethyl sulfoxide, compositions and processes for the preparation thereof, the use of this crystalline form in the treatment of a viral infection, and methods of treating viral infections using the same, and in particular, a viral infection caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2).

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