A first aggregated MAC protocol data unit (A-MPDU) is generated for transmission over a first frequency segment of a communication channel, and a second A-MPDU is generated for transmission over a second frequency segment of the communication channel. A PHY protocol data unit (PPDU) is generated to include the plurality of A-MPDUs and a second PPDU is generated to include the second A-MPDU. A first transmit processor generates a first RF signal for transmission of the first PPDU over the first frequency segment and a second transmit processor generates a second RF signal for transmission of the second PPDU over the second frequency segment. The first RF signal is transmitted in the first frequency segment simultaneously with the second RF signal being transmitted in the second frequency segment.