Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Chunhong Zhou0
Semyon Kruglyak0
Ryan Kelly0
Minghao Guo0
Haosen Wang0
Francisco Garcia0
Date of Patent
July 26, 2022
Patent Application Number
17547602
Date Filed
December 10, 2021
Patent Citations
Patent Citations Received
Patent Primary Examiner
Methods and systems for image analysis are provided, and in particular for identifying a set of base-calling locations in a flow cell for DNA sequencing. These include capturing flow cell images after each sequencing step performed on the flow cell, and identifying candidate cluster centers in at least one of the flow cell images. Intensities are determined for each candidate cluster center in a set of flow cell images. Purities are determined for each candidate cluster center based on the intensities. Each candidate cluster center with a purity greater than the purity of the surrounding candidate cluster centers within a distance threshold is added to a template set of base-calling locations.
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