Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Kallanthottathil G. Rajeev0
Klaus Charisse0
Martin Maier0
Muthiah Manoharan0
Satyanarayana Kuchimanchi0
Tracy Zimmermann0
Date of Patent
August 9, 2022
0Patent Application Number
168505550
Date Filed
April 16, 2020
0Patent Citations
...
Patent Primary Examiner
One aspect of the present invention relates to double-stranded RNAi (dsRNA) duplex agent capable of inhibiting the expression of a target gene. The dsRNA duplex comprises one or more motifs of three identical modifications on three consecutive nucleotides in one or both strand, particularly at or near the cleavage site of the strand. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA agents suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA agents, e.g., for the treatment of various disease conditions.
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