Is a
Patent attributes
Patent Applicant
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ying Hu0
Alexander O. Mujica0
Carmelo Romano0
Jeffrey D. Lee0
Lynn Macdonald0
Min Gao0
Susan D. Croll0
Yajun Tang0
Date of Patent
August 23, 2022
0Patent Application Number
162063300
Date Filed
November 30, 2018
0Patent Citations
Patent Primary Examiner
Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized TRKB locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized TRKB locus express a human TRKB protein or a chimeric transthyretin protein, fragments of which are from human TRKB. Methods are provided for using such non-human animals comprising a humanized TRKB locus to assess in vivo efficacy of human-TRKB-targeting reagents such as nuclease agents designed to target human TRKB.
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