A cart-based workflow system includes: a robot operating in a facility; a server, the server operably connected to the robot, the server configured to do one or more of send the robot a cart transfer location usable for transferring the cart and instruct the robot to specify the cart transfer location; a graphic user interface (GUI) comprising a map of the facility, the GUI operably connected to the server, the GUI configured to do one or more of receive input from a human user and provide output to the human user, the GUI further configured to be usable by the user to coordinate movement of one or more of robots and carts.