In an approach to image compression while retaining feature information at original coordinates, one or more computer processors compress an image while retaining pattern and feature information at original coordinates, wherein the image is a full resolution 3D image. The one or more computer processors create one or more image subsets based on the one or more determined regions of interest identified by utilizing a first pass selection of the regions of interest based on the compressed image. The one or more computer processors train one or more models based the created one or more image subsets that contain one or more regions of interest based on the compressed image.