A moisture-permeable waterproof shoe includes an outer shoe body unit including an outer shoe upper, a midsole and an outsole. The outer shoe upper and the midsole cooperatively define an insertion space. A sock-shaped inner shoe body unit is disposed in the insertion space and includes a moisture-permeable waterproof shoe-shaped inner sleeve, an outer sock body having a sock body portion sleeved on the shoe-shaped inner sleeve, and an inner adhesive layer adhered between an outer surface of the shoe-shaped inner sleeve and an inner surface of the sock body portion. A connecting layer is fixed between the outer shoe upper and the sock body portion and between the midsole and the sock body portion.