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US Patent 11446393 Non-viral gene delivery agent comprising lipopeptide (LP) compounds

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Patent
Patent
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Patent attributes

Patent Applicant
Monash University
Monash University
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Current Assignee
Monash University
Monash University
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
114463930
Date of Patent
September 20, 2022
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Patent Application Number
166221360
Date Filed
June 8, 2018
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Patent Primary Examiner
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Robert S Cabral
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CPC Code
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A61K 9/145
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A61K 9/146
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C12N 15/88
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A61K 9/0019
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A61K 48/0025
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Non-viral nucleic acid delivery agents and methods for the delivery or transfer of nucleic acid molecules to target cells are disclosed. The agents comprise a complex of a nucleic acid cargo for delivery, one or more lipopeptide compound, and one or more polymeric charge-neutralising agent, and the complex is in the form of a particle with substantially neutral or negative surface charge. The agents and methods may be useful in a variety of applications such as therapies (including gene therapies and nucleic acid vaccinations) for diseases and medical disorders.

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