A process for manufacturing tetrafluoropropene, including, alternately: at least one step of reacting a chlorinated compound with hydrofluoric acid in the gas phase, in the presence of a fluorination catalyst, the proportion of oxygen optionally present being less than 0.05 mol. % relative to the chlorinated compound; a step of regenerating the fluorination catalyst by bringing the fluorination catalyst into contact with a regeneration stream including an oxidizing agent. Also, equipment suitable for carrying out this process.