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US Patent 11459297 Crystalline form of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1H-pyrrol-3-yl)-N-methylmethanamine salt

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Patent
Patent

Patent attributes

Patent Applicant
Daewoong Pharmaceutical Co., Ltd
Daewoong Pharmaceutical Co., Ltd
Current Assignee
Daewoong Pharmaceutical Co., Ltd
Daewoong Pharmaceutical Co., Ltd
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
11459297
Date of Patent
October 4, 2022
Patent Application Number
17151901
Date Filed
January 19, 2021
Patent Citations
‌
US Patent 10913715 Crystalline form of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1H-pyrrol-3-yl)-N-methylmethanamine salt
‌
US Patent 10889545 Crystalline form of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1H-pyrrol-3-yl)-N-methylmethanamine salt
‌
US Patent 10100010 4-methoxy pyrrole derivatives or salts thereof and pharmaceutical composition comprising the same
‌
US Patent 10336695 Crystalline form of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1H-pyrrol-3-yl)-N-methylmethanamine salt
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US Patent 10487053 Acid addition salt of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1H-pyrrol-3-yl)-N-methylmethanamine
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US Patent 10683268 Crystalline form of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1H-pyrrol-3-yl)-N-methylmethanamine salt
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US Patent 10710961 Method for preparing intermediate of 4-methoxypyrrole derivative
Patent Primary Examiner
‌
Golam M. Shameem
CPC Code
‌
C07D 207/48
‌
A61K 31/40

The present invention provides a novel crystalline form I of hydrochloride, a crystalline form II of hydrochloride, a crystalline form of succinate, a crystalline form of tartrate, a crystalline form I of fumarate and a crystalline form II of fumarate of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1H-pyrrol-3-yl)-N-methylmethanamine. The above-described novel crystalline forms have high solubility in water and excellent stability under moisture-proof conditions and high-humidity exposure conditions, and thus can be pharmaceutically used.

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