A high-pressure vessel mounting structure includes: a plurality of high-pressure vessels arranged on the upper surface of a bottom wall in a front-rear direction of a vehicle body with a vehicle width direction as an axial direction; a plurality of load transmission members each provided between the high-pressure vessels on the bottom wall and extending along the axial direction; a connection member that connects one axial end of each of the high-pressure vessels; and a support member that supports the other axial end of each of the high-pressure vessels, and the support member can move relatively inward in the vehicle width direction with respect to the high-pressure vessel when a load is input from outside in the vehicle width direction.