An intelligent lock guard device, including a box body, the box body includes an upper box cover and a lower box body being buckled to form a hollow box body; the protection lock, including a lock catch and a lock body mechanism; the lock catch includes a fixing crossbeam and a locking rod, the fixing crossbeam is fixed on the upper box cover, and the locking rod is provided with a locking hole; the locking body mechanism, including a lock shaft, a toothed belt and a motor; the locking body mechanism is fixed on the lower box body; the lock shaft is provided with a lock cylinder convex bar, and the track of the toothed belt is parallel to the direction in which the lock cylinder convex bar is inserted or removed from the locking hole.