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Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ellalahewage Sathyajith Kumarasinghe0
Vladimir Presnyak0
Stephen Hoge0
Paolo Martini0
Kerry Benenato0
Iain McFadyen0
Date of Patent
November 22, 2022
0Patent Application Number
165152560
Date Filed
July 18, 2019
0Patent Citations
Patent Citations Received
Patent Primary Examiner
The disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human methylmalonyl-CoA mutase precursor, human methylmalonyl-CoA mutase (MCM) mature form, or functional fragments thereof. In some embodiments, the disclosure includes methods of treating methylmalonic acidemia in a subject in need thereof comprising administering an mRNA encoding an MCM polypeptide.
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