Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
December 20, 2022
Patent Application Number
16061435
Date Filed
December 15, 2016
Patent Citations
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Patent Citations Received
Patent Primary Examiner
The present invention discloses cell lines and recombinant growth factor receptors useful in adoptive cell therapy (ACT), wherein the recombinant growth factor receptor can act as a molecular switch enabling cells expressing the rGFR protein to be expanded in-vitro or in- vivo. Thus the invention provides a T or NK cell, comprising a recombinant growth factor receptor (rGFR) comprising: (i) an extracellular (EC) domain; (ii) a thrombopoietin receptor transmembrane (TM) domain; and (iii) a growth factor receptor intracellular (IC) domain.
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