Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Sean Stevens0
Andrew J. Murphy0
Margaret Karow0
Lynn Macdonald0
John McWhirter0
Date of Patent
January 24, 2023
0Patent Application Number
167031160
Date Filed
December 4, 2019
0Patent Citations
...
Patent Primary Examiner
Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human V
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