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Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
James Joseph Collins0
Feng Zhang0
Omar Abudayyeh0
Jonathan Gootenberg0
Angela Early0
Daniel Neafsey0
Eric S. Lander0
Date of Patent
April 4, 2023
0Patent Application Number
159521320
Date Filed
April 12, 2018
0Patent Citations
Patent Primary Examiner
The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.
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