Is a
Patent attributes
Patent Applicant
Patent Jurisdiction
Patent Number
Patent Inventor Names
Rachel Sattler0
Leah Sabin0
Lori Morton0
Qing Fang0
Brian Zambrowicz0
Chia-Jen Siao0
Dan Chalothorn0
KehDih Lai0
Date of Patent
April 11, 2023
0Patent Application Number
168943020
Date Filed
June 5, 2020
0Patent Citations
Patent Primary Examiner
Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized albumin (ALB) locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized albumin locus express a human albumin protein or a chimeric albumin protein, fragments of which are from human albumin. Methods are provided for using such non-human animals comprising a humanized albumin locus to assess in vivo efficacy of human-albumin-targeting reagents such as nuclease agents designed to target human albumin.
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