The present disclosure relates to identifying and authenticating samples of biological material such as human tissue samples, especially when such samples are passed from one entity, institution or holding bank to another. In some aspects, a sample Exchange acts as a bio hub in a bio exchange environment, and receives biosamples and associated data from one or more sample collection entities. The Exchange generates and associates a trusted and unique genetic code (UGC) based on the genetic content of a sample, which is carried forward to subsequent sample users in a chain of transactions in said sample, securely identifying and authenticating a physical and digital asset to avoid mistake or fraud in the transfer of said assets.