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US Patent 11679132 Methods for enhancing efficacy of therapeutic immune cells

Patent 11679132 was granted and assigned to National University of Singapore on June, 2023 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

National University of Singapore

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Current Assignee

National University of Singapore

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Date of Patent

June 20, 2023

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Patent Application Number

178627210

Date Filed

July 12, 2022

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Patent Citations

US Patent 8796427 Humanized anti-human NKG2A monoclonal antibody

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US Patent 9181527 T cell receptor-deficient T cell compositions

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US Patent 9273283 Method of producing T cell receptor-deficient T cells expressing a chimeric receptor

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US Patent 9683042 T-cell-specific humanized single fragment antibody delivery vehicle

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US Patent 9902936 PAN-KIR2DL NK-receptor antibodies and their use in diagnostics and therapy

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US Patent 10273280 Chimeric antigen receptors (CARs), targeting hematologic malignancies, compositions and methods of use thereof

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US Patent 10550183 Blockade of CD7 expression and chimeric antigen receptors for immunotherapy of T-cell malignancies

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US Patent 10730942 Protein-based T-cell receptor knockdown

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Patent Citations Received

US Patent 12129485 Blockade of CD2 surface expression and expression of chimeric antigen receptors for immunotherapy of T-cell malignancies

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US Patent 11945865 Blockade of CD7 expression and chimeric antigen receptors for immunotherapy of T-cell malignancies

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Patent Primary Examiner

Maria G Leavitt

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The present invention relates to a method of using a receptor (e.g., chimeric antigen receptor—CAR) that activates an immune response upon binding a cancer cell ligand in conjunction with a target-binding molecule that targets a protein or molecule for removal or neutralization to generate enhanced anti-cancer immune cells. The present invention also relates to engineered immune cells having enhanced therapeutic efficacy and uses thereof.

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