Systems and methods for multi-directional imaging in coupling with an indentation device are provided. The systems and methods can enable in situ multi-directional and full-field interfacial force response on soft matter. With more than two two-dimensional (2D) plane videos and/or images, the in situ nano-, micro-, and meso-scale time-dependent damage responses at the three-dimensional (3D) level can be constructed. Based on the obtained 2D and 3D videos and/or images, the underlying dynamic force response and fatigue mechanisms can be observed using a digital image correlation technique.