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Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Date of Patent
June 27, 2023
0Patent Application Number
164831850
Date Filed
March 1, 2018
0Patent Citations
Patent Primary Examiner
The present invention provides heterodimeric antibodies and fragments thereof and methods for their preparation, wherein the pairing of heavy and light chains has been improved. Interface residues were mutated such that each light chain strongly favoured its cognate heavy chain when two different heavy chains and two different light chains were co-transfected and co-expressed in the same cell to assemble a functional, heterodimeric antibody or fragment thereof.
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