US Patent 11697675 EPHA3 and multi-valent targeting of tumors
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US Patent 11697675 EPHA3 and multi-valent targeting of tumors
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Provided herein is a construct comprising, in combination: an EphA3, EphA2 and/or EphB2 binding ligand; and at least one effector molecule. In some embodiments, the at least one effector molecule comprises a therapeutic agent, a nanoparticle, a detectable group, a lipid, or a liposome. In some embodiments, the construct is a fusion protein and/or a covalent conjugate. Further provided is a construct comprising, in combination: a ligand that binds to EphA2, EphA3 and/or EphB2; a ligand that binds to IL-13Rα2; and at least one effector molecule. Also provided are methods of use thereof for treating cancer.
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Patent Jurisdiction
Patent Number
116976750
Date of Patent
July 11, 2023
0Patent Application Number
169471540
Date Filed
July 21, 2020
0Patent Citations
Patent Primary Examiner
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