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US Patent 11702401 Compounds and methods of use

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 US Patent 11702401 Compounds and methods of use

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This disclosure provides compounds and compositions and methods of using those compounds and compositions to treat diseases and disorders associated with excessive transforming growth factor-beta (TGFβ) activity. This disclosure also provides methods of using the compounds in combination with one or more cancer immunotherapies.

Infobox
Is a
Patent
Patent
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
117024010
Date of Patent
July 18, 2023
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Patent Application Number
173277050
Date Filed
May 22, 2021
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Patent Citations
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US Patent 7087603 Pyrazole compounds useful as protein kinase inhibitors
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US Patent 7098330 Pyrazolylamine substituted quinazoline compounds useful as protein kinase inhibitors
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US Patent 7115739 Triazole compounds useful as protein kinase inhibitors
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US Patent 7151110 Pyrazole compounds as transforming growth factor (TGF) inhibitors
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US Patent 7153872 Imidazole compounds as transforming growth factor (TGF) inhibitors
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US Patent 7189733 Compositions and methods for inhibiting TGF-β
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US Patent 7199123 Pyrazine compounds as transforming growth factor (TGF) compounds
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US Patent 7223766 Bi-cyclic pyrimidine inhibitors of TGFβ
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US Patent 7232824 Quinazoline derivatives as medicaments
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US Patent 7235559 Therapeutic quinazoline derivatives
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US Patent 7273936 Oxazole and thiazole compounds as transforming growth factor (TGF) inhibitors
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US Patent 7314939 Compositions and methods for inhibiting TGF-β
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US Patent 7345045 Pyrido-pyrimidine compounds as medicaments
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US Patent 7361669 Compositions and method for inhibiting TGF-β
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US Patent 7368445 Fused pyrazole derivatives as TGF-β signal transduction inhibitors for the treatment of fibrosis and neoplasms
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US Patent 7390815 Pyrazole compounds useful as protein kinase inhibitors
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US Patent 7390907 Vanilloid receptor ligands and their use in treatments
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US Patent 7417041 Imidazopyrimidines as transforming growth factor (TGF) inhibitors
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US Patent 7488740 Substituted quinolin-4-ylamine analogues
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US Patent 7511056 TGF-β inhibitors
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US Patent 7635702 Imidazole compounds as transforming growth factor (TGF) inhibitors
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US Patent 7638537 Pyrazole compounds as transforming growth factor (TGF) inhibitors
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US Patent 7691853 Pyrazole compounds useful as protein kinase inhibitors
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US Patent 7745451 Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and dysfunctions
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US Patent 7767687 Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors
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US Patent 7943640 Compositions and methods for inhibiting TGF-β
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US Patent 7977342 HCV inhibiting bi-cyclic pyrimidines
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US Patent 7982037 Pyrazole compounds useful as protein kinase inhibitors
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US Patent 8022077 Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and methods for the preparation thereof
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US Patent 8030318 Fused bicyclic inhibitors of HCV
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US Patent 8268857 Compositions and methods for inhibiting TGF-β
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US Patent 8426425 Aminopyrimidines useful as inhibitors of protein kinases
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US Patent 8450335 2,4-disubstituted pyrimidines useful as kinase inhibitors
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US Patent 8987301 Heteroarylaminoquinolines as TGF-beta receptor kinase inhibitors
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US Patent 9617243 Aminopyridyloxypyrazole compounds
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US Patent 10030000 Acesulfame potassium compositions and processes for producing same
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Patent Primary Examiner
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Sarah Pihonak
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CPC Code
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C07D 213/82
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C07D 213/72
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C07D 213/73
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C07D 471/04
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C07D 413/14
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C07D 405/14
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C07D 401/14
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C07D 401/12
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C07D 487/04
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A61P 9/00
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A61P 9/10
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A61P 43/00
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A61P 35/00
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A61P 29/00
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A61P 27/02
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A61P 19/10
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A61P 17/00
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A61P 17/02
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A61K 31/506
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A61K 31/4709
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A61K 31/4545
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A61K 31/444
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A61K 31/4439
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A61P 13/12
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A61P 11/00
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A61P 11/02
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A61P 1/16
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