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US Patent 11702473 Site-specific antibody-drug conjugates

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Date of Patent

July 18, 2023

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Patent Application Number

166842220

Date Filed

November 14, 2019

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Patent Citations

US Patent 7407951 Pyrrolobenzodiazepines

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US Patent 8829184 Intermediates useful for the synthesis of pyrrolobenzodiazepines

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US Patent 8940733 Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases

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US Patent 9321774 Pyrrolobenzodiazepines

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US Patent 9376440 Pyrrolobenzodiazepines as antiproliferative agents

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US Patent 9399641 Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates

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US Patent 9624227 Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases

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US Patent 9889207 Pyrrolobenzodiazepines and conjugates thereof

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Site-specific antibody-drug conjugates are described, in particular conjugates comprising pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker. The site of conjugation, along with modification of the antibody moiety, allows for improved safety and efficacy of the ADC.

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